GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7894051 | 1 | rs7070635 | chr10:135190127 | ECHS1 | chr10:135175988-135186908:- | -0.42 | -6.58 | 1.23E-10 | Lifespan |
| THCA | cis | rs11190604 | 1 | rs7070776 | chr10:102264672 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.69 | 5.7E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs7071271 | chr10:102264824 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.53 | 1.88E-16 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs6585827 | 1 | rs7072204 | chr10:124195485 | PLEKHA1 | chr10:124134220-124191866:+ | -0.21 | -5.89 | 7.48E-9 | Height |
| THCA | cis | rs7072216 | 1 | rs7072216 | chr10:100156853 | PYROXD2 | chr10:100143323-100174978:- | 0.96 | 29.61 | 3.26E-110 | Metabolite levels |
| THCA | cis | rs12780845 | 1 | rs7072634 | chr10:17240918 | TRDMT1 | chr10:17184983-17243681:- | -0.44 | -10.12 | 6.22E-22 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs7072634 | chr10:17240918 | VIM | chr10:17270258-17279592:+ | -0.18 | -3.41 | 0.0007 | Homocysteine levels |
| THCA | cis | rs12220238 | 1 | rs7073432 | chr10:75953350 | VCL | chr10:75754951-75879912:+ | -0.21 | -3.87 | 0.000125 | Soluble interleukin-2 receptor subunit alpha |
| THCA | cis | rs17109512 | 1 | rs7073497 | chr10:100153688 | PYROXD2 | chr10:100143323-100174978:- | 0.53 | 5.39 | 1.11E-7 | Aspartate aminotransferase |
| THCA | cis | rs11190604 | 1 | rs7073586 | chr10:102307671 | SEC31B | chr10:102246403-102289636:- | -0.29 | -9.33 | 3.82E-19 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs7923609 | 1 | rs7073746 | chr10:64904071 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -6.54 | 1.59E-10 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7894051 | 1 | rs7074435 | chr10:135190570 | ECHS1 | chr10:135175988-135186908:- | 0.55 | 7.77 | 4.88E-14 | Lifespan |
| THCA | cis | rs2797685 | 1 | rs707472 | chr1:7906008 | VAMP3 | chr1:7831329-7841491:+ | 0.2 | 3.48 | 0.000538 | Crohn's disease |
| THCA | cis | rs7075426 | 1 | rs7075426 | chr10:88216402 | WAPAL | chr10:88195014-88281541:- | -0.1 | -3.68 | 0.000263 | Migraine without aura |
| THCA | cis | rs2222800 | 1 | rs7076120 | chr10:54340942 | DKK1 | chr10:54074041-54077416:+ | -0.25 | -4.69 | 3.59E-6 | Metabolite levels (X-11787) |